In this important, practical, and timely edition of AntiplateletWRAP, Dr Sunil Rao, an expert in the field of interventional cardiology and bleeding, discusses issues related to antiplatelet therapy with the thienopyridine, clopidogrel, focusing on the relationship between clopidogrel use and bleeding complications in the setting of CABG surgery.

In this "science-to-strategy" installment of ACS-WRAP®, Dr Harold L. Dauerman reviews the evolution of STEMI and acute coronary syndromes (ACS) therapy, and discusses the integration of bivalirudin into modern cardiovascular (CV) practice for patients with STEMI and high-risk ACS.

In this edition of STEMI-WRAP, Dr. Gregg Stone, a leader in the field of interventional cardiology trials, begins by discussing the adverse consequences of bleeding in general and the potential advantages of the direct thrombin inhibitor bivalirudin. He then describes the results of past trials of bivalirudin in ACS and PCI, namely REPLACE-2 and ACUITY, and then gives a detailed analysis of the results of HORIZONS-AMI, a trial of bivalirudin monotherapy versus heparin plus GP IIb/IIIa therapy in patients with STEMI undergoing PCI.

In this important, practical, and timely edition of AntiplateletWRAP, Dr Sunil Rao, an expert in the field of interventional cardiology and bleeding, discusses issues related to antiplatelet therapy with the thienopyridine, clopidogrel, focusing on the relationship between clopidogrel use and bleeding complications in the setting of CABG surgery.

In this evidence-based, practice-focused edition of STEMI-WRAP, Dr Charles V. Pollack discusses the epidemiology and pathophysiology of STEMI, ACC/AHA guidelines for STEMI treatment, general principles for ED STEMI management, new trials focused on antiplatelet therapy, and recommendations for antiplatelet and antithrombin therapy in patients with STEMI.